|Title||Interfering strategies in exRNA communication: translational applications|
|Leader||Lionel Navarro (LN)|
|Rationale & Objectives|
|Although significant amounts of research data on exRNA communication is continuously produced by researchers, there is a gap in translating basic research into application and biotechnology due to a lack of researcher-toindustry connection. To overcome this gap, WG3 will assemble networks of academics and companies that co-ordinately bundle knowledge gain of exRNA-PATH in terms of exRNA biodiversity, functions and mechanisms that will help to develop new RNA-based interfering strategies for applications in biotechnology and drug delivery. We will take advantage of the breadth of knowledge and experience in infection systems in exRNA-PATH to identify the gaps in treatment options in infectious disease where exRNA-based applications and therapies could have maximal impact. WG3 will align research questions and research approaches in order to develop interfering strategies of exRNA communication (R-SOB3).
We have built into our network industrial representation and will prioritize identifying variables that must be further considered and addressed for sustainable translational outcomes (C-SOB2).
|Tasks & Activities|
|· Run a wiki instance on the exRNA-PATH webpage to share implementation ideas for interfering strategies.
· Integrate information from functional studies of exRNA communication in plant and animal infection models with cross-disciplinary perspective on microbiome and infection biology.
· Organize 3 match-making events to establish new collaborations between researchers and industry representatives (stakeholders) to foster and accelerate translational processes.
· Organise 2 WG meetings per year (online or in-person), 1 mid-term review, and 2 STSMs/year.
|Execution & Membership|
|· Researchers studying exRNAs for disease control in diverse biological systems.
· Industry partners with interest in exploiting exRNA achievements in new innovation applications.
· Collaborate with WG1 and WG2 to receive input on biological diversity, functions and mechanisms of exRNA communication and deliver interfering strategies to be tested.
· Collaborate with WG4 for communication and dissemination with the stakeholders and the public.
|Milestones (M) & Deliverables (D)|
|M5||Release an instance on the exRNA-PATH webpage to share implementation ideas and interfering strategies.|
|M6||Release a road map for strategies to interfere with or to engineer exRNA communication, such as artificial RNA target mimics, synthetic RNA/EV formulations, synthetic RNA carriers for targeted delivery.|
|M2||The mid-term review to map progress of WG3.|
|D6||Publish strategy papers on how to realize innovative applications in health and agriculture by utilizing the gained knowledge of exRNAs that will be acquired through exRNA-PATH.|
|D7||Release a white paper on the long-term strategy to contribute to the one-health concept and SDGs.|
|D3||Joint publication with all WGs: reports on data resources, analysis guidelines, original case- studies and reviews in open access journals.|